CRRT is explained as Continuous renal replacement therapy and Continuous dialysis that requires 4 hours to perform, but needs 24 hours a day with critical care of patients with severe kidney disease as it is much gentler on the liver, as compared to daily dialysis that lasts 3-4 hours. An article by Tolwani in the New England Medicine Journal demonstrated CRRT's potential to extract solutions (waste) and to fluidize more gently than traditional dialysis. It is important, as the death rate has been recorded to be more than 50% for chronically ill patients with severe kidney defects that require dialysis. Nevertheless, CRRT is often a complex treatment and involves the correct application of specialized skills from doctors and nurses. That’s why it is additionally known as ICU dialysis in scientific language.

Citrate is the yellowish material that the doctor's office used to extract blood and prevent coagulation or coagulation of the blood at the edge of the tubes. In 2004, Tolwani developed a new type of citrate-based anticoagulant solution that made CRRT safer, simpler, and more global. It is also being used in several countries including-: